Involvement of angiotensin II type 2 receptor (AT2R) signaling in human pancreatic ductal adenocarcinoma (PDAC): a novel AT2R agonist effectively attenuates growth of PDAC grafts in mice
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منابع مشابه
SIRT 1 Overexpression is Associated with Metastasis of Pancreatic Ductal Adenocarcinoma (PDAC) and Promotes Migration and Growth of PDAC Cells
BACKGROUND SIRT 1, as a class III histone deacetylase (HDAC), is implicated in the initiation and progression of malignancies. However, the association of SIRT 1 with tumorigenesis or progression of pancreatic ductal adenocarcinoma (PDAC) is not clear. MATERIAL AND METHODS In our study we investigated SIRT 1 expression in PDAC samples and evaluated the association of SIRT 1 level with the clini...
متن کاملNeurotensin is a Versatile Modulator of In Vitro Human Pancreatic Ductal Adenocarcinoma Cell (PDAC) Migration
BACKGROUND While the neurotensin (NT) roles in pancreatic cancer growth are well documented, its effects on pancreatic cancer cell migration have not been described. METHODS The NT-induced effects on the migration process of human pancreatic ductal adenocarcinoma cells (PDACs) were characterized by means of various assays including computer-assisted video-microscopy, fluorescence microscopy, ...
متن کاملP-218: Investigation of Association between Angiotensin II Type 1 and 2 Receptor (AT1R & AT2R) Gene Polymorphisms and Susceptibility to Pre-Eclampsia (PE) in Iranian Women
Background: Hypertension during pregnancy period along with the presence of protein in the urine, after the 20th weeks of gestation is called preeclampsia (PE). About five percent of all pregnancies are manifested with PE and its exact etiology has still remained unknown. The renin-angiotensin system (RAS) has an important role in the regulation of blood pressure during pregnancy and so pathoph...
متن کاملNeuroprotective effects of angiotensin II type 1 receptor (AT1R) blocker, telmisartan, via modulating AT1R and AT2R signaling in retinal inflammation.
PURPOSE To investigate the retinal neural damage that occurs during inflammation and the therapeutic effects of the angiotensin II type 1 receptor (AT1R) blocker, telmisartan, using a model of endotoxin-induced uveitis (EIU). METHODS The localization of AT1R and AT2R was shown by immunohistochemistry. EIU was induced by intraperitoneal injection of lipopolysaccharide (LPS). Animals were treat...
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ژورنال
عنوان ژورنال: Cancer Biology & Therapy
سال: 2015
ISSN: 1538-4047,1555-8576
DOI: 10.1080/15384047.2014.1002357